Roles of DMP1 Processing in Osteogenesis, Dentinogenesis and Chondrogenesis
نویسندگان
چکیده
منابع مشابه
Roles of DMP1 processing in osteogenesis, dentinogenesis and chondrogenesis.
Dentin matrix protein 1 (DMP1) is an acidic protein that plays critical roles in osteogenesis and dentinogenesis. Protein chemistry studies have demonstrated that DMP1 primarily exists as processed NH₂⁻ and COOH-terminal fragments in the extracellular matrix of bone and dentin. Our earlier work showed that the substitution of Asp²¹³ (a residue at a cleavage site) by Ala²¹³ blocks the processing...
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ژورنال
عنوان ژورنال: Cells Tissues Organs
سال: 2011
ISSN: 1422-6421,1422-6405
DOI: 10.1159/000324672